Pharmaceutical Drugs and Dosage: Capsules - Review questions answers
Review questions
21.1 Why
should highly soluble chloride salts not be dispensed in hard gelatin capsules?
A. Capsules will
dissolve slowly
B. Salts will decompose
C. Rapid release may
cause gastric irritation
D. The capsule shell
will disintegrate
21.2 The main
difference between soft and hard gelatin capsules is
A. The level of
plasticizer
B. Hard gelatin shells
are not plasticized
C. Hard gelatin shells
are plasticized
D. The basic
composition of soft shells is not gelatin
E. Dyes are added to
the capsule shell
21.3 Leakage
from soft gelatin capsules can be caused by
A. Hydrolysis of
gelatin at low pH
B. Addition of
surfactants
C. Addition of
polyethylene glycol
D. All of the above
21.4 The
ideal powder characteristics for successful filling of hard gelatin capsules include
A. Poor compatibility
B. Poor lubrication
C. Have adequate flow
properties
D. Have low bulk
density
21.5 The
decrease in solubility of gelatin capsules has been attributed to
A. Acid hydrolysis
B. Gelatin
cross-linking
C. Trace amount of
glycine
D. None of the above
21.6 Following is a commonly used plasticizer in soft gelatin
capsules
A. Polyethylene glycol
B. Polypropylene glycol
C. Glycerol
D. Sorbitol
Answers:
21.1 C.
21.2 A.
21.3 A.
21.4 C.
21.5 B.
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