Pharmaceutical Industrial Management

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Pharmaceutical Industrial Management




PART I: INTRDUCTORY CHAPTERS



Chapter 1: Drug discovery


=> Drug discovery
=> Collaborating disciplines
=> Small - versus large-molecule paradigms
=> Contemporary drug discovery case studies
=> Summary and outlook to the future
=> Review questions and answers

Chapter 2: Drug development


=> Drug development
=> Stage-gate process of new drug discovery and development
=> Pharmaceutical development
=> Regulatory approval
=> Postcommercialization activities
=> Review questions and answers

Chapter 3: Pharmaceutical considerations


=> Pharmaceutical considerations
=> Advantages of pharmaceutical dosage forms
=> Influential factors in dosage form design
=> Review questions and answers

Chapter 4: Biopharmaceutical considerations


=> Biopharmaceutical considerations
=> Diffusion: Drug transport across a polymeric barrier
=> Principles of diffusion
=> Diffusion rate
=> Dissolution
=> Absorption
=> Review questions and answers

Chapter 5: Pharmacy math and statistics


=> Pharmacy math and statistics
=> Systems of measure
=> Ratio and proportion
=> Concentration calculations
=> Clinical dose calculations
=> Statistical measures
=> Tests of statistical significance
=> Review questions and answers

PART II: PHYSICOCHEMICAL PRINCIPLES



Chapter 6: Complexation and protein binding


=> Complexation and protein binding
=> Types of complexes
=> Protein binding
=> Review questions answers

Chapter 7: Chemical kinetics and stability


=> Chemical kinetics and stability
=> Reaction rate and order
=> Factors affecting reaction kinetics
=> Drug degradation pathways
=> Stabilization strategies
=> Review questions answers

Chapter 8: Interfacial phenomena


=> Interfacial phenomena
=> Liquid–liquid and liquid-gas interfaces
=> Solid-gas interface: Adsorption
=> Solid-Liquid interface
=> Biological and pharmaceutical applications
=> Review questions answers

Chapter 9: Colloidal dispersions


=> Colloidal dispersions
=> Types of colloidal systems
=> Preparation of colloidal solutions
=> Properties of colloidal solutions
=> Physical stability of colloids
=> Review questions answers

Chapter 10: Surfactants and micelles


=> Surfactants and micelles
=> Surfactants
=> Types of surfactants
=> Hydrophile-lipophile balance system
=> Micelles
=> Factors affecting critical micelle concentration and micellar size
=> Micellar solubilization
=> Review questions answers

Chapter 11: Pharmaceutical polymers


=> Pharmaceutical polymers
=> Definitions and architectures of polymers
=> Polymer molecular weight and weight distribution
=> Biodegradablity and biocompatibility
=> Physicochemical properties and solubility
=> Block copolymers
=> Intelligent or stimuli-sensitive polymers
=> Water-soluble polymers
=> Bioadhesive/mucoadhesive polymers
=> Review questions answers

Chapter 12: Rheology


=> Rheology
=> Newtonian flow
=> Non-Newtonian flow
=> Thixotropy
=> Pharmaceutical applications of rheology
=> Review questions answers

Chapter 13: Radiopharmaceuticals


=> Radiopharmaceuticals
=> Biomedical applications of radiopharmaceuticals
=> Radiation detection equipment
=> Formulation of radiopharmaceuticals
=> Calculations of Radiopharmaceuticals
=> Review questions answers

Chapter 14: Drug delivery systems


=> Drug delivery systems
=> Targeted drug delivery
=> Prodrugs
=> Soluble macromolecular carriers
=> Particulate carrier systems
=> Oral drug delivery
=> Alternative routes of delivery
=> Review questions answers

Chapter 15: Organ-specific drug delivery


=> Organ-specific drug delivery
=> Need for alternate, nonoral routes to the systemic circulation
=> Need for organ specific and targeted drug delivery
=> Local drug delivery to the lung
=> Systemic drug delivery through the lung
=> Devices for pulmonary drug delivery
=> Ocular drug delivery
=> Brain targeted drug delivery
=> Liver-targeted drug delivery
=> Colon-targeted drug delivery
=> Combination and other strategies for colon targeting
=> Review questions answers

PART III: DOSAGE FORMS



Chapter 16: Suspensions


=> Suspensions
=> Types of suspensions
=> Powder for suspension
=> Quality attributes
=> Formulation considerations
=> Manufacturing process
=> Review questions answers

Chapter 17: Emulsions


=> Emulsions
=> Types of emulsions
=> Quality attributes
=> Formulation considerations
=> Emulsification
=> Manufacturing process
=> Stability
=> Review questions answers

Chapter 18: Pharmaceutical solutions


=> Pharmaceutical solutions
=> Types of solutions
=> Quality attributes
=> Formulation components and manufacturing process
=> Solubility
=> Stability
=> Review questions answers

Chapter 19: Powders and granules


=> Powders and granules
=> Production of powders and granules
=> Analyses of powders
=> Particle shape and size - Analyses of powders
=> Surface area - Analyses of powders
=> Density and porosity - Analyses of powders
=> Flow - Analyses of powders
=> Compactibility - Analyses of powders
=> Content uniformity - Analyses of powders
=> Powder processing
=> Powders as dosage forms
=> Review questions answers

Chapter 20: Tablets


=> Tablets
=> Types of tablets
=> Tablet formulation
=> Manufacturing of tablets
=> Evaluation of tablets
=> Relationship among disintegration, dissolution, and absorption
=> Review questions answers

Chapter 21: Capsules


=> Capsules
=> Hard gelatin capsules
=> Soft gelatin capsules
=> Evaluation of capsule drug products
=> Shelf-life tests
=> Review questions answers

Chapter 22: Parenteral drug products


=> Parenteral drug products
=> Parenteral routes of administration
=> Types of parenteral dosage forms
=> Quality attributes and evaluation
=> Formulation components
=> Sterilization
=> Review questions answers

Chapter 23: Semisolid dosage forms


=> Semisolid dosage forms
=> Ointments and Types of ointment bases
=> Creams
=> Gels and jellies
=> Lotions
=> Pastes
=> Foams
=> Manufacturing processes
=> Analysis of semisolid dosage forms
=> Review questions answers

Chapter 24: Inserts, implants, and devices


=> Inserts, implants, and devices
=> Ocular inserts, Suppositories, Vaginal rings
=> Implants and Types of implants
=> Devices
=> Review questions answers

Chapter 25: Protein and peptide drug delivery


=> Protein and peptide drug delivery
=> Structure of Proteins and peptides
=> Types of protein and peptide therapeutics
=> Protein characterization
=> Instability
=> Antigenicity and immunogenicity
=> Drug product formulation and process
=> Review questions answers

Chapter 26: Biotechnology-based drugs


=> Biotechnology-based drugs
=> Gene and gene expression
=> Gene silencing
=> Gene silencing technologies
=> Gene therapy
=> Review questions answers

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