Suspension is the dispersion of a solid in a liquid or gas. A pharmaceutical suspension is the dispersion of solid particles (usually a drug) in a liquid medium (usually aqueous) in which the drug is not readily soluble.
Dosage forms
Suspensions
Introduction
Suspension
is the dispersion of a solid in a liquid or gas. A pharmaceutical suspension is
the dispersion of solid particles (usually a drug) in a liquid medium (usually
aqueous) in which the drug is not readily soluble. This dosage form is used for
providing a liquid dosage form for insoluble drugs. The particle size of the
dispersed phase in most of the oral pharmaceutical suspensions is between 1 and
50 μm. The lower the
particle size, the larger the surface area of the suspended drug. Lower
particle size allows the for-mation of a uniform, fine particle suspension with
low grittiness and high redispersibility. A larger surface area of the
dispersed drug promotes rapid drug dissolution on dilution with biological
fluids upon administration.
Aerosols,
suspensions of a solid or a liquid in a gas (e.g., air), are special-ized
dosage forms used for pulmonary drug delivery. These dosage forms are discussed
in Chapter 15.
In
addition to the use of aqueous pharmaceutical suspensions as drug products,
suspensions are also used as in-process materials during indus-trial
pharmaceutical manufacturing. For example, tablets are coated with a suspension
of insoluble coating materials. Granules manufactured by wet-granulation
processes are typically suspended in the air for drying dur-ing fluidized
bed-drying process. In addition, wet granulation could be carried out on
granules suspended in the air in a process called fluid-bed granulation.
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