Pharmaceutical Drugs and Dosage: Organ-specific drug delivery - Review questions answers
Review questions
15.1 Which of
the following routes of drug administration does not bypass the hepatic first-pass
metabolism?
A. Oral route of drug
delivery
B. Sublingual
absorption of a drug
C. Transdermal route of
drug delivery
D. Vaginal route of
drug absorption
15.2 Which of
the following is not a barrier to the absorption of lipophilic molecules across the
epithelial cell lining of the blood–brain barrier?
A. Metabolizing enzymes
B. Efflux transporters
C. Liophilic cell
membrane
D. Intercellular tight
junctions
15.3 Which of
the following cell types is primarily responsible for the secretion of fibrinogen
in damaged liver, which contributes to hepatic cirrhosis?
A. Hepatocytes
B. Kupffer cells
C. Hepatic stellate
cells
D. Epithelial cells
15.4 Which of
the following routes of drug administration into the eye is subjected to tear clearance
and blinking-associated tear loss as a bar-rier to drug absorption?
A. Retrobulbar route
B. Intravitreal route
C. Subtenon route
D. Topical route
15.5 Which of
the following types of chemical bonds is utilized for colonic drug targeting through
enzymatic cleavage by the resident anaerobic bacteria to release the parent
drug?
A. Azo bonds
B. Ester bonds
C. Ether bonds
D. Amide bonds
15.6 Which of
the following is not a strategy to achieve drug release in the latter parts of the
intestinal tract after oral drug administration?
A. Enteric coating
B. Osmotic pump-based
sustained drug release
C. pH-dependent drug
release
D. Time-dependent drug
release
15.7 Which of
the following is not a contributing factor to the low oral bioavailability of protein and peptide drugs?
A. Large hydrodynamic
diameter
B. Overall hydrophilic
nature
C. Cleavage of peptide
bonds by enzymes and the pH environment
D. Presence of side
chains on the amino acids constituting the pep-tide backbone
15.8 Which of
the following strategies for drug delivery and targeting necessarily require
covalent modification of the drug molecule?
A. Liposomes
B. Micelles
C. Nanoparticles
D. Prodrugs
15.9 Which of
the following strategies increases the circulation half-life of a drug by avoidance
of the reticuloendothelial cell system (RES) uptake?
A. PEGylation
B. Liposomal
incorporation
C. Prodrug strategy
D. Incorporation in a
micelle
15.10 Which of
the following modes of drug absorption does not depend on the concentration
gradient of the drug?
A. Passive transport
across endothelial cell membranes of the blood–brain barrier
B. Drug absorption
across the sublingual tissue
C. Transporter-mediated
drug uptake
D. Drug transport
across the tight junctions between the endothelial cells
Answers:
15.1 A.
15.2 D.
15.3 C.
15.4 D.
15.5 A.
15.6 B.
15.7 D.
15.8 D.
15.9 A.
15.10 C.
Related Topics
TH 2019 - 2023 pharmacy180.com; Developed by Therithal info.