Pharmaceutical Drugs and Dosage: Drug discovery - Review questions and Answers
Review questions
1.1 What is
the one significant difference between antibodies from hydro-phobic
small-molecule drugs?
A. Antibodies are
hydrophilic.
B. Antibodies are large
molecular weight compounds.
C. Antibodies typically
have slow off rates on receptors that they occupy.
D. All of the above.
1.2 What is
the sequence of activities in the new drug development?
A. Preclinical
development > clinical development > compound characterization >
commercialization
B. Compound
characterization > preclinical development > clinical development >
commercialization
C. Clinical development
> preclinical development > compound characterization >
commercialization
1.3 All drugs intended
for human administration must be manufactured and released by utilizing
practices that conform to which of the fol-lowing? Check any two that apply.
A. Good manufacturing
practices
B. Good clinical
practices
C. Good laboratory
practices
D. The International
Council on Harmonisation
1.4 Please
categorize the number of subjects tested in clinical trials in the increasing order of the
different phases of clinical studies.
A. Phase 1 > phase 2
> phase 3
B. Phase 1 > phase 3
> phase 2
C. Phase 2 > phase 1
> phase 3
D. Phase 2 > phase 3
> phase 1
E. Phase 3 > phase 2
> phase 1
F. Phase 3 > phase 1
> phase 2
1.5 Typical
toxicology studies must be carried out in how many different species of animals
before first human administration of a new drug candidate?
A. 1
B. 2
C. 3
D. 4
E. 5
1.6 Which of the
following is not an analytical method used to test the quality of a drug?
A. Purity
B. Potency
C. Quantity
D. Water content
Answer:
1.1 D.
1.2 B.
1.3 A, C.
1.4 E.
1.5 B.
1.6 C.
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