Exercises and lanthanum carbonate tablets Case study
| Home | | Inorganic Pharmaceutical Chemistry |Chapter: Essentials of Inorganic Chemistry : The Clinical Use of Lanthanoids
Research the properties and clinical use of lanthanum carbonate tablets.
Exercises
1. Write the
electronic configuration for the following:
(a)
La
(b)
La2+
(c)
Eu
(d)
Eu3+
(e)
Er
(f)
Ce3+
2. Draw the Lewis
structures for the following compounds:
(a)
Lanthanum nitrate
(b)
Lanthanum sulfate
(c)
Lanthanum acetate
3. A typical
solution of Dotarem for injection is labelled with gadoteric acid, 0.5
mmol/ml/100 ml. Calculate
(a)
the amount of gadoteric acid in gram;
(b)
the corresponding amount of DOTA;
(c)
the corresponding amount of gadolinium oxide.
Case study: lanthanum carbonate tablets
Research the properties and clinical use of lanthanum carbonate
tablets. Summarise your findings in a drug monograph, which could be published
in a Pharmacopoeia. Your drug monograph should contain the following aspects:
1.
Chemical structure
2.
Action and use
(a)
Preparation
3.
Chemical formula
4.
Definition
5.
Content
6.
Characteristics
(a)
Appearance
(b)
Solubility
7.
Identification (two different forms of
identification)
(a)
Identification A
(b)
Identification B
8.
Assay to quantify the API (active
pharmaceutical ingredient)
9.
Impurities.
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