i. Bishydroxycoumarin (Dicoumarol) ii. Warfarin (Coumarin, Coumadia) iii. Heparin iv. Ethyl biscoumacetate v. Acenocoumarol
SYNTHESIS AND DRUG PROFILE
Synthesis
Properties and uses: It is used in postoperative thrombophlebitis,
pulmonary embolus, acute embolic, and thrombolic occlusion of peripheral
arteries.
Synthesis
Properties and uses: Warfarin sodium is a white hygroscopic powder,
soluble in water, alcohol, and acetone, very slightly soluble in methylene
chloride. The (–) (S) isomer of warfarin has shown itself to be five to eight
times more potent than (+) (R) enantiomer. Warfarin is a synthetic anticoagulant
used in patients undergoing orthopaedic surgery.
Assay: Dissolve the sample in 0.01 M sodium hydroxide and measure the
absorbance after dilution at the maxima of 308 nm using ultraviolet
spectrophotometer.
Dose: The dose for adults is 10–15 mg per day for 2 to 4 days.
Dosage forms: Warfarin tablets I.P., B.P.
Properties and uses: Heparin sodium is a white hygroscopic powder,
soluble in water and used as an anticoagulant.
Assay: It is assayed by adopting spectrophotometric method.
Dosage forms: Heparin injection B.P.
Properties and uses: Acenocoumarol is a white to buff-coloured
powder, practically insoluble in water and ether, slightly soluble in ethanol.
It dissolves in aqueous solutions of the alkali hydroxides. Used as vitamin K
epoxide reductase inhibitor and as oral anticoagulant.
Assay: Dissolve the sample in acetone and titrate against 0.1 M sodium
hydroxide using bromothymol blue as indicator.
Dosage forms: Acenocoumarol tablets B.P.
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