Two-Compartment Open Model: Intravenous Infusion
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The model can be depicted as shown below with elimination from the central compartment.
Two-Compartment Open Model
Intravenous Infusion
The model can be depicted as shown below with
elimination from the central compartment.
The plasma or central compartment concentration of
a drug that fits two-compartment model when administered as constant rate
(zero-order) i.v. infusion, is given by equation:
At steady-state (i.e. at time infinity), the second
and the third term in the bracket becomes zero and the equation reduces to:
Now VcKE = Vdß.
Substituting this in equation 9.113, we get:
The loading dose Xo,L to obtain Css
immediately at the start of infusion can be calculated from equation:
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