Oligosaccharide Structure

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Chapter: Biochemistry : Glycosaminoglycans, Proteoglycans, and Glycoproteins

The oligosaccharide components of glycoproteins are generally branched heteropolymers composed primarily of D-hexoses, with the addition in some cases of neuraminic acid (a nonose) and of L-fucose, a 6-deoxyhexose.


OLIGOSACCHARIDE STRUCTURE

The oligosaccharide components of glycoproteins are generally branched heteropolymers composed primarily of D-hexoses, with the addition in some cases of neuraminic acid (a nonose) and of L-fucose, a 6-deoxyhexose.

 

A. Structure of the linkage between carbohydrate and protein

The oligosaccharide may be attached to the protein through an N- or an O-glycosidic link. In the former case, the sugar chain is attached to the amide group of an asparagine side chain and, in the latter case, to the hydroxyl group of either a serine or threonine side chain. [Note: In the case of collagen, there is an O-glycosidic linkage between galactose or glucose and the hydroxyl group of hydroxylysine.]

 

B. N- and O-linked oligosaccharides

A glycoprotein may contain only one type of glycosidic linkage (N- or O-linked) or may have both types within the same molecule.

 

1. O-Linked oligosaccharides: The O-linked oligosaccharides may have one or more of a wide variety of sugars arranged in either a linear or a branched pattern. Many O-linked oligosaccharides are found in extracellular glycoproteins or as membrane glycoprotein components. For example, O-linked oligosaccharides on the surface of red blood cells help provide the ABO blood group determinants.

 

2. N-linked oligosaccharides: The N-linked oligosaccharides fall into two broad classes: complex oligosaccharides and high-mannose oligosaccharides. Both contain the same pentasaccharide core shown in Figure 14.14, but the complex oligosaccharides contain a diverse group of additional sugars, for example, GlcNAc, GalNAc, L-fucose, and NANA, whereas the high-mannose oligosaccharides contain primarily mannose.


Figure 14.14 Complex (top) and high-mannose (bottom) N-linked oligosaccharides. [Note: Members of each class contain the same pentasaccharide core.] NANA = N-acetylneuraminic acid; Gal = galactose; GlcNAc = N-acetylglucosamine; Man = mannose; Fuc = fucose; Asn = asparagine.

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